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Total Synthesis of Trioxacarcin DC‐45‐A2 |
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| Authors: | Prof. Dr. K. C. Nicolaou Dr. Quan Cai Dr. Bo Qin Mette T. Petersen Remi J. T. Mikkelsen Dr. Philipp Heretsch |
| Affiliation: | Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, TX 77005 (USA) |
| Abstract: | An enantioselective total synthesis of trioxacarcin DC‐45‐A2 ( 1 ) featuring a novel Lewis acid‐induced cascade rearrangement of epoxyketone 6 to forge the polyoxygenated 2,7‐dioxabicyclo[2.2.1]heptane core of the molecule is described. |
| Keywords: | antitumor agents cascade reactions natural products total synthesis trioxacarcins |