General Method for the Synthesis of Salicylic Acids from Phenols through Palladium‐Catalyzed Silanol‐Directed CH Carboxylation |
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Authors: | Yang Wang Prof. Dr. Vladimir Gevorgyan |
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Affiliation: | Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Room 4500, Chicago, IL 60607 (USA) http://www.chem.uic.edu/vggroup |
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Abstract: | A silanol‐directed, palladium‐catalyzed C? H carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional‐group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o′‐disubstituted phenolic compound through two sequential C? H functionalization processes. |
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Keywords: | C H activation carboxylation palladium phenols salicylic acids |
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