Regiospecific synthesis of 4-alkoxy and 4-amino substituted 2-trifluoromethyl pyrroles |
| |
| Authors: | Zanatta Nilo Schneider Juliana M F M Schneider Paulo H Wouters Ana D Bonacorso Helio G Martins Marcos A P Wessjohann Ludger A |
| |
| Affiliation: | Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, CEP-97105-900, Santa Maria, RS, Brazil. zanatta@base.ufsm.br |
| |
| Abstract: | A simple and regiospecific synthesis of 4-alkoxy(amino)-2-trifluoromethyl pyrroles from 5-azido-4-alkoxy(amino)-1,1,1-trifluoro-pent-3-en-2-ones by an aza-Wittig cyclization of aminophosphoranes is described. The structures of the pyrroles and their synthetic intermediates were supported by NMR and HRMS analysis. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
