Preparation of Polymer-Supported Chiral 1,2-Diamine as an Efficient Ligand for Asymmetric Hydrogenation Catalyst |
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Authors: | Shinichi Itsuno Miyuki Takahashi Atsushi Tsuji |
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Institution: | Department of Materials Science, Toyohashi University of Technology, Tempaku-cho, 441-8580 Toyohashi, Japan |
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Abstract: | An enantiopure 1,2-diamine having two phenolic hydroxy groups was synthesized, and attached to chloromethylated poly(styrene) through a benzyl ether linkage. The polymer-supported Ru precatalysts were prepared from the polymeric chiral 1,2-diamine and RuCl2/BINAP complex. In the presence of t-BuOK the polymeric catalyst system worked well in asymmetric hydrogenation of aromatic ketones in a mixed solvent of 2-propanol and DMF. The insoluble polymeric catalyst was readily separated from the reaction mixture and reused at least several times without loss of the catalytic activity. |
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Keywords: | asymmetric hydrogenation 1 2-diamine ketone polymer-support |
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