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Persistence Length of Cartilage Aggrecan Macromolecules Measured via Atomic Force Microscopy |
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| Authors: | Laurel Ng Alan J. Grodzinsky John Sandy Anna Plaas Christine Ortiz |
| Affiliation: | 1. Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02114 USA;2. Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02114 USA Departments of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02114 USA Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02114 USA;3. Shriner's Hospital, Tampa;4. Departments of Pharmacology and Therapeutics and Internal Medicine, University of South Florida, Tampa, FL USA 33620;5. Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02114 USA |
| Abstract: | Tapping mode atomic force microscopy (TMAFM) was employed to directly calculate the persistence length of individual fetal bovine epiphyseal and mature nasal cartilage aggrecan monomers, as well as their constituent chondroitin sulfate glycosaminoglycan chains. |
| Keywords: | aggrecan atomic force microscopy biopolymers cartilage glycosaminoglycan |