Divergent asymmetric synthesis of hexahydrobenzophenanthridine dopamine D1 agonists,A-86929, and dihydrexidine |
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| Authors: | Rajesh Malhotra Sagar Chakrabarti Amit Ghosh Rajib Ghosh Tushar K. Dey Swarup Dutta Shantanu Dutta Subho Roy Sourav Basu Saumen Hajra |
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| Affiliation: | 1. Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India;2. TCG Life Sciences Ltd, Saltlake, Kolkata 700091, India;3. Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India |
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| Abstract: | A divergent and scalable asymmetric synthesis of the dopamine D1 agonists, A-86929, and dihydrexidine with high diastereo- and enantioselectivity was accomplished from Weinreb amide 8 derived from inexpensive and easily available l-serine. The synthesis of A-86929 involves only one chromatographic purification. |
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