One-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones catalyzed by amino acid-derived sulfonamides |
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Authors: | Haixing Zheng Qi Liu Saishuai Wen Hua Yang Yiming Luo |
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Affiliation: | School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China |
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Abstract: | An organocatalyzed approach to the asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones using amino-acid derived sulfonamides as organocatalysts, which can be easily prepared starting from l-proline, l-alanine, and l-phenylalanine, has been developed in high yields (up to 92%) and with moderate to good enantioselectivities (up to 74% ee). Additionally, opposite enantioselectivities for primary and secondary amino acid sulfonamides have also been observed. |
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