Total synthesis of emericellamides A and B |
| |
| Authors: | Tapan Kumar Pradhan Karla Mahender Reddy Subhash Ghosh |
| |
| Institution: | CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India |
| |
| Abstract: | A concise total synthesis of emericellamides A and B, two cyclic depsipeptides exhibiting antibacterial and cytotoxic activities, is reported. A Paterson anti-aldol reaction and a hydroxy directed 1,3-anti reduction were applied for construction of the polypropionate unit with the required stereochemistry in emericellamides A and B. An FDPP mediated macrolactamization was used to construct the macrocycle of emericellamides A and B. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
