Stereoselective total synthesis of Ieodomycin A and B |
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| Authors: | Emmadi Narender Reddy Atmakur Krishnaiah Tadikamalla Prabhakar Rao |
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| Institution: | 1. Crop Protection Chemical Division, Indian Institute of Chemical Technology, Hyderabad 500607, India;2. Centre for NMR & Structural Chemistry, Indian Institute of Chemical Technology, Hyderabad 500607, India |
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| Abstract: | The stereoselective total synthesis of Ieodomycin A and B, bioactive secondary metabolites from marine sources with potent anti-microbial activity was achieved starting from commercially available geranial. The key steps involved in the synthetic sequence of Ieodomycin A and B are the Sharpless asymmetric epoxidation, the formation of a β-ketoester, and the 1,3-anti reduction. The synthesis of C-3 epimer of Ieodomycin A and B was also accomplished in good yields. |
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