Stereoselective total synthesis of Jaspine B (Pachastrissamine) utilizing iodocyclization and an investigation of its cytotoxic activity |
| |
Authors: | Partha Ghosal Sama Ajay Sanjeev Meena Sudhir Sinha Arun K Shaw |
| |
Institution: | 1. Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226 031, India;2. Drug Target Discovery and Development, CSIR-Central Drug Research Institute, Lucknow 226 031, India |
| |
Abstract: | The stereoselective synthesis of Jaspine B has been achieved from easily available (S)-Garner’s aldehyde. The trisubstituted tetrahydrofuran core of Jaspine B was constructed by utilizing a diastereoselective iodocyclization as the key step. Deiodination and debenzylation were performed in a single step by using n-Bu3SnH and ABCN as a conjugate catalyst system. The in vitro cytotoxicity of compounds 1 and 1a against 3 human cancer cell lines-A549 (lung), MCF7 (breast), and KB (oral); and a non-cancer cell line (NIH3T3) was determined by sulphorhodamine B based assay. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|