Synthesis and evaluation of a new non-cross-linked polystyrene supported hydantoin chiral auxiliary for asymmetric aldol reactions |
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| Authors: | Guang-Jun Lu Jun-Qi Nie Zu-Xing Chen Gui-Chun Yang Cui-Fen Lu |
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| Institution: | Hubei Collaborative Innovation Center for Advanced Organochemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, China |
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| Abstract: | A new non-cross-linked polystyrene supported chiral hydantoin was prepared and it was shown to be a particularly effective chiral auxiliary for asymmetric aldol reactions, affording high yields and excellent diastereoselectivity. Furthermore, the recovery and recycling of the polymer-supported chiral auxiliary have been successfully achieved without an appreciable reduction in the yield or diastereoselectivity. |
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