Efficient Heck cross-coupling of 3-iodo-benzopyrones with olefins under microwave irradiation without phosphine |
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Authors: | Yikai ZhangZhiliang Lv Hanyu ZhongMingfeng Zhang Tao ZhangWannian Zhang Ke Li |
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Institution: | Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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Abstract: | An efficient and effective microwave-assisted Heck cross-coupling of different terminal olefins with various 3-iodo-benzopyrones including sterically hindered, electron-rich, electron-neutral, and electron-deficient is developed. It proceeded faster and generally gave good to excellent yields under microwave irradiation, phosphine-free, and air condition. The reaction could render this method particularly attractive for the efficient preparation of biologically and medicinally interesting molecules. |
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Keywords: | Heck reaction 3-Iodo-benzopyrone Microwave Phosphine-free |
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