Multiple-Scattering-Free Optical Glucose Monitoring Based on Femtosecond Pulse Interferometry |
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Authors: | Yasuaki Hori Takeshi Yasui Tsutomu Araki |
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Institution: | (1) Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan |
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Abstract: | We have designed a novel multiple-scattering-free optical glucose monitoring system based on femtosecond pulse interferometry. The glucose concentration is determined by a time-of-flight method, while multiple-scattering light is rejected by a coherence gate. The resultant accuracy and precision were 94.7 and 24.5 mg/dl, respectively, for physiological-equivalent glucose concentrations in a scattering medium of 1.0% intralipid solution, while the accuracy and precision for a reference sample containing no scattering medium were 65.3 and 23.8 mg/dl, respectively. Comparing these results, we conclude that the proposed method is effective for glucose measurement in a scattering medium. |
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Keywords: | glucose femtosecond pulse light multiple scattering coherence gate interferometry time-of-flight group refractive index |
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