Supported TBD-assisted solution phase diversification of formyl-aza-heterocycles through alkylation-knoevenagel one pot sequences |
| |
| Authors: | El Maatougui Abdelaziz Crespo A Silva Artur M S Coelho Alberto |
| |
| Institution: | Combinatorial Chemistry Unit (COMBIOMED), Institute of Industrial Pharmacy (IFI), University of Santiago de Compostela, Spain. |
| |
| Abstract: | An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
