Studies on the determination and degradation of pyrimethamine in mammals |
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| Authors: | R Kumar P Kaushik C B Sharma |
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| Affiliation: | Department of Biosciences and Biotechnology, University of Roorkee, India. |
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| Abstract: | Treatment of pyrimethamine with blood plasma in vitro yields a metabolite which is also produced when the drug is administered through intravenous injection in the rat. A thin layer liquid chromatographic method for quantitative and qualitative determination of pyrimethamine and its metabolite in plasma and biological tissues is described. |
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