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Acetylenchemie 7. Mitt.: Mechanistische Studien zur Synthese von Pyrano-[3,2-c]chinolin-Alkaloiden aus 4-Hydroxychinolin-2-onen und 3-Chlor-3-methylbut-1-in |
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| Authors: | Johannes Reisch Reza A. Salehi-Artimani Andreas Bathe Michael Müller |
| Affiliation: | (1) Institut für Pharmazeutische Chemie, Universität Münster, D-4400 Münster, Bundesrepublik Deutschland |
| Abstract: | The pyrano-cyclisation of 4-hydroxy-(1-methyl)-1H-quinoline-2-one with 3-chlor-3-methylbut-1-yne, supposed to proceed via an ether or vinyl intermediate, is studied by alkylating different 4-hydroxyquinolines. The nine derivatives characterized favour the ether-pathway ( Späth type chromene synthesis). |
| Keywords: | Pyrano[3,2-c]quinoline-alkaloids 4-Hydroxyquinoline-2-ones Alkylation Phase-transfer-catalysis Sigmatropic rearrangement |
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