Total synthesis of A-315675 based on the cascade Overman rearrangement |
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| Authors: | Takayuki Momose |
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| Affiliation: | Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan |
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| Abstract: | The chiral and stereoselective total synthesis of A-315675 1, an antiinfluenza agent, is described. The vicinal diamino moiety in 1 was stereoselectively constructed by the cascade Overman rearrangement of a vicinal allylic-homoallylic diol derived from d-tartrate. |
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| Keywords: | A-315675 Antiinfluenza agent Total synthesis Cascade Overman rearrangement |
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