Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties |
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Authors: | Raman Vysabhattar |
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Institution: | a Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India b Indian Institute of Science Education and Research, 900, NCL Innovation Park, Dr. Homi Bhabha Road, Pune 411 008, India |
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Abstract: | The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N′-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer. |
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Keywords: | PNA Cyanuryl PNA |
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