类二十烷酸分析方法及应用的研究进展

类二十烷酸是一大类由二十碳多不饱和脂肪酸氧化产生的具有生物活性的不饱和脂肪酸,是重要的炎症因子,广泛存在于体液和组织中,调节体内众多生理和病理过程。类二十烷酸在生物体内种类众多,含量较低,并且存在大量同分异构体,因此生物体内类二十烷酸的分离和分析具有较大的挑战。本文对近5年来类二十烷酸的分析方法和其在生物样品分析中的应用进行归纳总结,重点介绍了不同分析方法的特点及其在生物样品分析中的最新进展,旨在为类二十烷酸的体内药物分析及应用研究提供参考。

Recent advances in the methods and applications used to analyze eicosanoids

Eicosanoids are a large family derived from polyunsaturated fatty acids, including prostaglandins, thromboxanes and leukotrienes. They are biologically active lipid mediators and are known to play an important role in numerous physiological and pathophysiological processes, such as inflammation. This complete enzymatic system produces hundreds of eicosanoids derived from arachidonic acids and related polyunsaturated fatty acids with very similar structures, chemistries and physical properties which makes the analysis of eicosanoids a challenging task, especially in biological samples. In this article, we review and discuss the methods and applications published over the last five years that have been used to analyze eicosanoids in biological samples, and emphasize the recent advances and the latest developments.