| 阿达玛变换显微图象分析系统在乳腺肿瘤细胞DNA倍性分析中的应用研究 |
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| 引用本文： | 唐宏武,梅二文,陈观铨,曾云鹗,毛永荣,何平,史宗洁.阿达玛变换显微图象分析系统在乳腺肿瘤细胞DNA倍性分析中的应用研究[J].高等学校化学学报,1997(2). |
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| 作者姓名： | 唐宏武 梅二文 陈观铨 曾云鹗 毛永荣 何平 史宗洁 |
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| 作者单位： | 武汉大学化学系!武汉，430072，武汉大学分析测试科学系!武汉，430072，武汉大学分析测试科学系!武汉，430072，武汉大学化学系武汉!430072，湖北省肿瘤医院!武汉，430070，湖北省肿瘤医院!武汉，430070，湖北省肿瘤医院!武汉，430070 |
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| 基金项目： | 国家自然科学基金，湖北省自然科学基金 |
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| 摘 要： | 以正常人外周静脉血淋巴细胞为标准二倍体细胞，以吖啶橙为细胞DNA荧光探针，用阿达玛变换显微图象分析仪测定了六例乳腺肿瘤的细胞DNA含量（倍性），分析结果与病例学诊断结论吻合，表明该仪器可望用于乳腺癌的诊断和预后研究．研究结果还表明：乳腺肿瘤细胞DNA倍性与核面积（象素）呈显著正相关．
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| 关 键 词： | 阿达玛变换 图象分析 乳腺癌 DNA倍性 |
DNA Ploidy Analysis of Breast Tumor Cell by the System of Hadamard Transform Microscopic Image Analysis |
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| TANG Hong-Wu, MEl Er-Wen, CHEN Guan-Quan, ZENG Yun-E.DNA Ploidy Analysis of Breast Tumor Cell by the System of Hadamard Transform Microscopic Image Analysis[J].Chemical Research In Chinese Universities,1997(2). |
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| Authors: | TANG Hong-Wu MEl Er-Wen CHEN Guan-Quan ZENG Yun-E |
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| Abstract: | Normal human lymphocyte was used as standard diploid cell, acridine orange was used as fluorescence probe for DNA in cell, and DNA ploidy of six cases of human breast tumor was analyzed by the system of Hadamard transform microscopic image analysis. Some parameters were employed to evaluate tumor malignancy, the results are concordant with pathological diagnosis, this indicates that the above instrument may be applied in diagnostic and prognostic study on human breast cancer. The results also show that significant positive correlation exists between tumor cell nuclear DNA ploidy and its area (pixels). |
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| Keywords: | Hadamard transform Image analysis Breast cancer DNA ploidy |
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