Synthesis and characterization of glycosylated nitrogen mustard derivatives and their interaction with bovine serum albumin |
| |
Authors: | Shan Li He-ping Li Long Qin |
| |
Affiliation: | 1. College of Chemical and Biologic Engineering, Changsha University of Science and Technology, Changsha, 410004, China
|
| |
Abstract: | To improve the specificity of nitrogen mustards towards tumor cells, glucose-nitrogen mustard, fructose-nitrogen mustard, and lactose-nitrogen mustard were prepared as three novel glycosylated nitrogen mustard derivatives by esterification of bis(2-chloroethyl)carbamic chloride (BCC) with glucose, fructose, and lactose, respectively. BCC was synthesized from bis(2-chloroethyl)amine hydrochloride and triphosgene. The topic products were characterized by infrared (IR) and mass spectrometry (MS), and their interaction with bovine serum albumin was investigated by measuring fluorescence spectra in tris(hydroxymethyl)aminomethane hydrochloride (Tris–HCl) buffer solution at physiological conditions. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|