A novel synthetic method for preparation of some folates |
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| Authors: | Minghao Zhou Mei Hong Guomin Xiao |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210094, People’s Republic of China
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| Abstract: | An improved method was developed for preparation of 5,6,7,8-tetrahydrofolic acid (THF) and calcium-5-methyltetrahydrofolate (5-MTHF-Ca) by reduction of folic acid using KBH4 catalyzed by Pb(NO3)2. The yields of THF and 5-MTHF-Ca were 56.5 and 42.7 %, respectively. A convenient method for measurement of THF and 5-MTHF-Ca using liquid chromatography–mass spectrometry (LC–MS) was also established, enabling analysis of those folates within 10 min without application of gradient elution. |
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