Scaffolded amino acids as a close structural mimic of type-3 copper binding sites |
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| Authors: | Albada H Bauke Soulimani Fouad Weckhuysen Bert M Liskamp Rob M J |
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| Affiliation: | Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, NL-3508 TB Utrecht, The Netherlands. |
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| Abstract: | We report the use of triazacyclophane (TAC)-scaffolded amino acids as a structural mimic for 3-histidine metal-binding sites in metalloproteins, especially for the mimicry of type-3 copper binding sites as are present in hemocyanin, tyrosinase and catechol oxidase. |
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