The condensation reaction between isocyanates and carboxylic acids. A practical synthesis of substituted amides and anilides. |
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Affiliation: | 1. ICGM, Univ Montpellier, CNRS, ENSCM, Montpellier, France;2. IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France;3. TPF Industrie, MGH, Noves, France |
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Abstract: | Addition of a carboxylic acid to an isocyanate initially yields the mixed acid anhydride, decarboxylation of which leads to the N-substituted amide. The conversion of acid into amide was shown to proceed similarly for both aliphatic and aromatic carboxylic acids with a range of substituted isocyanates. |
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