New approach to the synthesis of deoxynucleoside-phosphoramidite derivatives |
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| Affiliation: | 1. Department für Chemie, Universität für Bodenkultur, 1190 Wien, Austria;2. Institut für Parasitologie, Veterinärmedizinische Universität Wien, 1210 Wien, Austria;3. Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada;4. Institutionen för Biomedicin, Göteborgs universitet, 405 30 Göteborg, Sweden |
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| Abstract: | A new method for the synthesis of deoxyribonucleoside-phosphoramidite via an intermediate, 5′-0-dimethoxytritylthymidine-3′-0-diisopropylamino-phosphorochloridite, is reported. By using this method, several deoxyribonucleoside phosphoramidite derivatives with different protecting groups at phosphorus including PS and PN bond besides PO bond were synthesized. |
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