Total synthesis of leukotriene (+)-LTB4 from D-mannitol1 |
| |
| Affiliation: | 1. Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 5000 007, India;2. Center for Material Characterization, CSIR-National Chemical Laboratory, Pune 411008, India;1. Department of Physiology & Developmental Biology, Brigham Young University, Provo, UT 84602, USA;2. Tolero Pharmaceuticals, Inc., 2975 Executive Parkway, Suite 320, Lehi, UT 84043, USA;3. Division of Oncology of School of Medicine and Center for Investigational Therapeutics at Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA |
| |
| Abstract: | A total convergent synthesis of leukotriene (+)-LTB4 has been carried out via two enantiomerically pure α-hydroxyaldehydes,chiral key intermediates both obtained from D-mannitol and connected at a four carbon atoms interval by Wittig reactions. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
