Synthesis of the hexahydrobenzofuran subunit of the milbemycins and the avermectins |
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| Institution: | 1. Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, PR China;2. Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, PR China;3. State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China;1. Chemours Co., Fluorochemicals, 200 Powder Mill Rd. Experimental Station 262/339, PO Box 2167, Wilmington DE, 19899, United States;1. Helmholtz-Zentrum Dresden-Rossendorf, Institute of Fluid Dynamics, P. O. Box 510119, D-01314 Dresden, Germany;2. Theoretical and Applied Fluid Mechanics Laboratory, Faculty of Physics – USTHB, P. O. Box 32 El Alia Bab Ezzouar, 16111 Algiers, Algeria;1. Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, United States;2. RIKEN Center for Sustainable Resource Science, Saitama 351-0198, Japan;3. Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, United States |
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| Abstract: | A synthesis of the hexahydrobenzofuran subunit of milbemycins J and K has been accomplished in 17 steps from 4-methyl-1,4-pentadienol. |
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