Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid |
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| Affiliation: | 1. Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA;2. Dell Pediatric Research Institute and Dept. of Pediatrics, Dell Medical School, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA;3. Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA;4. Cayuga Medical Center, 101 Dates Drive, Ithaca, NY 14850, USA;5. Department of Chemistry, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA;1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland;2. Department of Animal Reproduction with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland |
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| Abstract: | Both enantiomers of the epoxygenase metabolites 8,9- and 11,12-epoxyeicosatrienoic acid (EET) were synthesized by a convergent strategy utilizing dimethyl D- or L-malate and erythrospecific epoxidation. |
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