Stereo- and regiospecific syntheses to provide conjugated (E,Z)- and (Z,Z)-alkadienes,and arylated (Z)-alkenes in excellent yields via the palladium-catalyzed cross-coupling reactions of (Z)-1-alkenylboronates with 1-bromoalkenes and aryl iodides |
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| Affiliation: | 1. Emory University School of Medicine, Atlanta, GA;2. Department of Surgery, University of South Florida, Tampa, FL;1. Laboratorio de Radioisótopos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina;2. Laboratorio de Efectos Biológicos de Contaminantes Ambientales, Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina;3. Instituto de Química y Fisicoquímica Biológicas “Prof. Alejandro C. Paladini”, IQUIFIB UBA-CONICET, Buenos Aires, Argentina;1. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;2. Department of Preventive Medicine, Mt. Sinai School of Medicine, New York, NY 10029, USA;3. Department of Epidemiology, Columbia University, New York, NY 10032, USA;4. Division of Epidemiology, Vanderbilt University, Nashville, TN 37203, USA;5. Department of Medicine, Columbia University, New York, NY 10032, USA |
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| Abstract: | Titled alkadienes are obtained in excellent yields stereo- and regiospecifically by cross-coupling between (Z)-1-alkenylboronates and (E)- or (Z)-1-bromoalkenes in the presence of a catalytic amount of Pd(PPh3)4 and sodium ethoxide. |
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