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Highly stereoselective intramolecular alkylation of ester enolate: An approach to trans-hydrindane system
Affiliation:1. Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan 316021, People’s Republic of China;2. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China;3. Zhejiang Key Laboratory of Gastro-Intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou 310006, People’s Republic of China;1. Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA;2. Department of Neurosurgery, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21287, USA;3. Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;1. Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 E4-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan;2. PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
Abstract:Highly diastereoselective intramolecular alkylation of acyclic ester system was developed based upon allylic strain concept as an approach to trans-hydrindane system.
Keywords:
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