New and stable endoperoxide from the pteridin-2,4,7-trione and singlet oxygen |
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| Affiliation: | 1. Service de cardiologie, hôpital général de Grand-Yoff, BP 3270, Dakar, Sénégal;2. Service de cardiologie, hôpital Aristide-Le-Dantecc, BP 6003, Dakar-Étoile, Sénégal;3. Service de médecine interne, hôpital Abass-Ndao, BP 5866, Dakar-Fann, Sénégal;4. Service de néphrologie, hôpital Aristide-Le-Dantec, BP 6003, Dakar-étoile, Sénégal;5. Institut de santé publique, université Cheikh-Anta-Diop, BP 16390, Dakar-Fann, Sénégal;6. Service de cardiologie, hôpital de Fann, BP 3053, Dakar-Fann, Sénégal;7. Centre de Santé de Guéoul, Guéoul Escale, 30900 Kébémer, Sénégal;1. Medicinal Chemistry Research Division, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, India;2. Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands;3. Clinical Research Department, Emcure Pharmaceuticals Ltd., Pune, India;1. Shenyang Pharmaceutical University, Shenyang 110016, China;2. Yanbian University, Yanji 133000, China;3. Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | 1,3,8-Trimethyl-6-phenylpteridin-2,4,7-trione (1) reacted with singlet oxygen to give the pteridin-2,4,7-trione 6,8′-endoperoxide (2), which on warming generates singlet oxygen. Generation of singlet oxygen from thermolysis of the endoperoxide (2) was confirmed by trapping experiments using typical singlet oxygen acceptors. |
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