Deoxynucleoside H-Phosphonate diester intermediates in the synthesis of internucleotide phosphate analogues |
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| Affiliation: | 1. School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China;2. College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China;3. Engineering Research Center of Molecular Medicine, Xiamen 361021, China;1. College of Bioengineering, Beijing Polytechnic, Beijing 100029, China;2. The Second Affiliated Hospital of Dalian Medical University, Dalian 116044, China;3. College of Pharmacy, Dalian Medical University, Dalian 116044, China;1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmans’ka str., Kyiv 02660, Ukraine;2. Department of Organic Chemistry, National Technical University of Ukraine “Kyiv Polytechnic Institute”, 37, Prospect Peremogy, Kyiv 03056, Ukraine;1. College of Pharmacy, Shanxi Medical University, Taiyuan 030000, China;2. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100080, China;1. Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South Africa;2. University of Technology Sydney, School of Mathematical and Physical Sciences, P.O. Box 123, Broadway, Sydney, NSW 2007, Australia |
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| Abstract: | Polymer bound deoxynucleoside H-phosphonate diesters are used as precursors to phosphoramidate, thiophosphate and phosphate triester analogues of DNA. |
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