From theoretical calculations to the enantioselective synthesis of a 1,3,4-trisubstituted Gly-derived 2-azetidinone |
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Authors: | Paula Pérez-Faginas |
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Institution: | Instituto de Química Médica (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain |
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Abstract: | Theoretical calculations on the transition states of the cyclization of 2S-chloropropionyl amino acid derivatives to the corresponding β-lactams have served to explain the high stereoselectivity of the reaction, and have been the driving force to extend the procedure to the preparation of a Gly-derived 1,3,4-trisubstituted 2-azetidinone in enantiopure form. |
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