Highly site, regio-, and stereoselective multicomponent reaction of benzimidazole carbenes, isothiocyanates, and allenoates |
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Authors: | Bo Wang |
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Institution: | Chemistry Department, Beijing Normal University, Beijing 100875, China |
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Abstract: | The novel three-component reaction of benzimidazole carbenes with isothiocyanates and allenoates proceeded efficiently in a highly site, regio-, and stereoselective manner to produce predominantly spirobenzimidazoline-2,3′-tetrahydrothiophene] derivatives. The reaction was proposed to occur via a tandem nucleophilic addition of carbenes to isothiocyanates followed by an unusual 3+2] cycloaddition to the less activated carbon-carbon double bond of allenoates. |
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Keywords: | Three-component reaction Benzimidazole carbene Isothiocyanate Allenoate Spiro[benzimidazoline-2 3&prime -tetrahydrothiophene] |
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