The synthesis of pyrazolo[3,4-d]pyridazines. Photochemical cyclization to pyrazolo[3,4-d]pyridazin-4(5H)-ones with subsequent functionalization |
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Authors: | Kenji Kaji Hiromu Nagashima Yusho Ohta Keizo Tabashi Hirohisa Oda |
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Affiliation: | Gifu College of Pharmacy, 5–6–1, Mitahora-higashi, Gifu 502 Japan |
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Abstract: | The synthesis of 1,3-disubstituted and 1,3,5-trisubstituted 1H-pyrazolo[3,4-d]pyridazin-4(5H)-ones is conveniently performed by photochemical cyclization. Functionalization of the former compounds leading to the formation of 1,4-disubstituted and 1,3,4-trisubstituted 1H-pyrazolo[3,4-d]pyridazines is smoothly effected through pertinent nucleophilic substitutions. |
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