The synthesis of 1-substituted 6-amino-1H-pyrrolo-[3,2-c]pyridin-4(5H)-ones |
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| Authors: | Stewart W Schneller Jiann-Kuan Luo Ramachandra S Hosmane Rainer H DÚrrfeld |
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| Institution: | Department of Chemistry, University of South Florida, Tampa, Florida 33620 |
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| Abstract: | The synthesis of 1-methyl- ( 1a ) and 1-benzyl-6-amino-1H-pyrrolo3,2-c]pyridin-4(5H)-one ( 1b ) from the appropriate N-alkylaminoacetaldehyde is described. These provide examples of a synthetic procedure that can be used to prepare 1-substituted 6-amino-1H-pyrrolo3,2-c]pyridin-4(5H)-ones wherein the N-1 substituent is regiospecifically placed. |
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