RepEx: A web server to extract sequence repeats from protein and DNA sequences
Affiliation:
1. Biological Research Laboratories, Daiichi Sankyo, Co., Ltd., Tokyo, Japan;2. Department of Microbiology and Infection Control Science, Kyoto Pharmaceutical University, Yamashina, Kyoto, Japan;1. University of Helsinki, Helsinki University Hospital, Department of Obstetrics and Gynecology, Helsinki, Finland;2. University of Helsinki, Hyvinkää Hospital, Hyvinkää, Finland;3. THL, National Institute for Health and Welfare, Helsinki, Finland;4. Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Family Medicine, Stockholm, Sweden;1. Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh, India;2. Department of Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;1. Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, United States;2. Computational Genomics Department, National Institute of Genomic Medicine (INMEGEN), Mexico;3. Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México (UNAM), Mexico;4. Inorganic Chemistry Department, Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico;1. Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, United States;2. Department of Anesthesiology and Operation Center, Chinese PLA General Hospital, Beijing 100853, China;3. Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China;1. WIL Research Laboratories, Ashland, OH, United States;2. Ashland, OH, United States;3. University of Michigan, Ann Arbor, MI, United States;4. Biologics Consulting Group, Alexandria, VA, United States;5. SNBL USA, Everett, WA, United States;6. Exponent, Inc., Alexandria, VA, United States;7. Georgetown University School of Medicine, Washington, DC, United States
Abstract:
Evolution builds up new genetic material from existing ones, not in random, but in highly ordered and eloquent patterns. Most of these sequence repeats are revelatory of valuable information contributing to areas of disease research and function of macromolecules, to name a few. In the age of next generation genome sequencing, rapid and efficient extraction of all unbiased sequence repeats from macromolecules is the need of the hour. In view of this reckoning, an online web-based computing server, RepEx, has been developed to extract and display all possible repeats for DNA and protein sequences. Apart from exact or identical repeats, the server has been designed adeptly to identify and extract degenerate, inverted, everted and mirror repeats from both DNA and protein sequences. The server has striking output displays, featuring interactive graphs and comprehensive output files. In addition, RepEx has been accoutered with an easy-to-use interface and search filters to facilitate a user-defined query or search and is freely available and accessible via the World Wide Web at http://bioserver2.physics.iisc.ac.in/RepEx/.
