Acyclo analogs of formycin a |
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Authors: | H Griengl F Günzl |
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Institution: | Institut für Organische Chemie, Technische Universität Graz, A-8010 Graz, Austria |
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Abstract: | Starting from 7-chloro-3-methyl-1H-pyrazolo4,3-d]pyrimidine ( 1 ) by reaction with methanol/hydrogen chloride, subsequent methylation and reaction with N-bromosuccinimide 3-bromomethyl-7-methoxy-1-methyl-1H-pyrazolo4,3-d]pyrimidine ( 6 ) is prepared. Treatment with ethylene glycol in the presence of potassium carbonate/potassium iodide and subsequent reaction with ethanolic ammonia afforded 7-amino-3-(2-hydroxyethoxymethyl)-1-methyl-1H-pyrazolo4,3-d]pyrimidine ( 11 ) an acyclo analog of formycin A. |
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