Synthesis of new derivatives of 4-amino-2,4-dihydro-1,2,4-triazol-3-one as potential antibacterial agents |
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| Authors: | Frédérique Malbec René Milcent Patrick Vicart Anne Marie Bure |
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| Affiliation: | 1. Laboratoire de Chimie Organique Medicale, Université Paris VII, Faculté de Médecine X. Bichat, 16 rue Henri Huchard, 75018 Paris, France;2. Laboratoire central de Microbiologie, Hôpital C. Bernard, 10 avenue de la Porte d'Aubervilliers, 75019 Paris, France |
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| Abstract: | Thirty new 2-substituted-4-amino-5-alkyl or aryl-2,4-dihydro-1,2,4-triazol-3-ones and ten 2-substituted-5-alkyl or aryl-4-(5-nitro-2-furfurylidene)amino-2,4-dihydro-1,2,4-triazol-3-ones were synthesized and characterised by their sharp melting points, elemental analysis, ir and 1H nmr spectra. These new derivatives of 5-nitro-2-furaldehyde were screened for their antibacterial activities. Most of the compounds showed good activity against one test organism, Staphylococcus aureus. For a few compounds, C.M.I. ranged from 4 to 8 μg/ml (higher results than nitrofurantoin). |
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