Synthesis of α-Oxo and α-hydroxy-1-benzyl-1,4-dihydro-3(2H)-isoquinolinones |
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| Authors: | Paolo Sanna Francesco Savelli |
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| Affiliation: | 1. Istituto di Chimica Farmaceutica e Tossicologica dell'Università, via Muroni 23/a, 07100 Sassari, Italy;2. Istituto di Scienze Farmaceutiche, Università di Genova, via Benedetto XV 3, 16132 Genova, Italy |
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| Abstract: | The reaction of some primary amines with the methyl 2-[(α-oxobenzyl)-(α-bromo)methyl]phenylacetate ( 5 ) afforded the isoquinolinones 7a-d , which in turn were hydrogenated to 10a-d . The synthesis of these compounds was designed on the basis of a potential depressant and antiinflammatory activity found in other structurally related compounds. |
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