The synthesis of thienocycloheptenoindoles |
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| Authors: | Belén Abarca Rafael Ballesteros Gurnos Jones |
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| Affiliation: | 1. Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain;2. Department of Chemistry, University of Keele, Keele, Staffordshire, ST5 5BG, United Kingdom |
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| Abstract: | A synthesis of the methylthieno[3,2-c]cyclohepteno[b]indole 7 from 2-methylthieno[3,2-b]cycloheptanone 3 is described. Unsuccessful attempts to prepare the isomeric thienocycloheptenoindole system present in formula 2 , from the dihydrobenzothiophenone 8 , and from derivatives of 5-(2-thienyl)-4-oxopentanoic acid, 17 and 18 , and from N-benzylcycloheptindol-1-one 22 were unsuccessful. The preparation of 4,5-dihydro-2-phenyl-1-thienylmethyl-3H-pyridazin-3-one 20 and of the 5-aminopyrazole 21 are reported. |
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