Reactivities of 3-(1-Azolyl)-2-alken-1-ones and the related compounds with pyrrolidine |
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| Authors: | Choji Kashima Tadakuni Tajima Chihiro Higuchi Yoshimori Omote |
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| Institution: | Department of Chemistry, University of Tsukuba, Sakura-mura, Niihari-gun, Ibaraki 305, Japan |
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| Abstract: | From the rate constants of the reaction with pyrrolidine, the reactivities of 3-(1-azolyl)-2-alken-1-ones with nucleophiles were evaluated to be rather high. Especially the reactivities of the quaternary salts of 3-(1-imidazolyl)-2-alken-1-ones were nearly equal to those of 3-chloro-2-alken-1-ones. In conclusion, 3-(1-imidazolyl)-2-alken-1-ones satisfied the practical requirements for the starting materials of the synthesis of 3-hetero-substituted 2-alken-1-ones. |
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