Synthesis and biological activity of some new 3-and 6-substituted coumarin amino acid derivatives. Part I |
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| Authors: | A M El-Naggar F S M Ahmed A M Abd El-Salam M A Radi M S A Latif |
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| Institution: | Chemistry Department, Faculty of Science, Al-Azhar University, Nasr-City, Cairo, Egypt, A. R. Egypt |
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| Abstract: | The synthesis of 6-nitrocouarrain-3-CO-amino acids and their corresponding methyl esters (II-XVII) and some dipeptide methyl esters (XVIII-XXVI) are described. 6-(N-Tosyl- or N-phthalylaminoacyl)aminocoumarin-3-carboxylic acid methyl esters (XXXIV-XL) and 3-(N-phthalyl- or N-tosylaminoacytyaminocoumarins (XLV-LVI) have been prepared via the carbodiimide and acid chloride methods. Hydrazinolysis of 3- or 6-(N-phthalylaminoacyl)aminocoumarin derivatives in tetraline gave the corresponding 3- and 6-(aminoacyl)aminocoumarins and the carboxylic acid hydrazides (XLI-LVIII), respectively. 3-(N-Tosyl-L-Val-L-Leu-)aminocoumarin (LIX) was synthesized via the azide method. Twenty four of various substituted 3- and 6-aminoacylcoumarin derivatives were found to possess specific antimicrobial activities towards different microorganisms. |
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