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A novel synthesis of precursors to 3-thienylmalonic acid |
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| Authors: | Peter W Raynolds |
| Institution: | Research Laboratories, Eastman Chemicals Division, Eastman Kodak Company, Kingsport, Tennessee 37662 |
| Abstract: | Methyl 2-cyano-2-(3-thienyl)acetate can be prepared in 95% yield by treating methyl 2-cyano-2-(3-tetra-hydrothienylidene)acetate with sulfuryl chloride, followed by dehydrohalogenation with pyridine. The product can be hydrolyzed to 3-thienylmalonic acid, a pharmaceutical intermediate. |
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