The regioselective alkylation of 4,6-dimethyl-1-phenyl-2(1H)-pyrimidinone |
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| Authors: | Akira Katoh Yoshimori Omote Choji Kashima |
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| Affiliation: | Department of Chemistry, University of Tsukuba, Sakura-mura, Niihari-gun, Ibaraki 305, Japan |
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| Abstract: | 4,6-Dimethyl-1-phenyl-2(1H)-pyrimidinone (I) was treated with alkyl halides in the presence of sodium hydride at low temperature to afford only C-6 alkylated products III and IV in good yields. Further, the mono-, IIIa-d, and di-alkylated 2(1H)-pyrimidinones IVa-d were selectively obtained by changing the amount of alkyl halides. |
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