Facile addition of methyl lithium to a 4-vinylpyridine system |
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| Authors: | David Miller |
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| Affiliation: | Beecham Pharmaceuticals Research Division, Medicinal Research Centre, Coldharbour Road, The Pinnacles, Harlow, Essex, CM19 5AD, England |
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| Abstract: | The rapid addition of methyl lithium to the 4-vinylpyridine system present in 4-{2,6-dihydroxy-4-(3-methyl-2-octyl)phenyl}-2-methyl-4-(4-pyridyl)but-3-en-2-ol ( 2 ) is reported. The α and β-4-{2,6-dihydroxy-4-(3-methyl-2-octyl)phenyl}-2,3-dimethyl-4-(4-pyridyl)butan-2-ols 4 and 5 formed, are cyclised by heating with 5N hydrochloric acid to trans and cis-3,4-dihydro-5-hydroxy-7-(3-methyl-2-octyl)-4-(4-pyridyl)-2,2,3-trimethyl-2H-1-benzopyran 6 and 7 respectively. |
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