Amine-salt-controlled, catalytic asymmetric conjugate addition of various amines and asymmetric protonation |
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Authors: | Hamashima Yoshitaka Somei Hidenori Shimura Yuta Tamura Toshihiro Sodeoka Mikiko |
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Institution: | Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Katahira, Sendai, Miyagi 980-8577, Japan. |
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Abstract: | The combined use of chiral Pd complex 2 and amine salt enabled completely regulated release of free nucleophilic amine. Under these conditions, an efficient catalytic asymmetric conjugate addition of various amines was achieved to afford beta-amino acid derivatives in high chemical yields with up to 98% ee. Furthermore, a highly enantioselective protonation in 1,4-addition of amine was also developed. reaction: see text] |
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