Changes of relaxation times T1 and T2 in rat tissues after biopsy and fixation |
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| Authors: | R L Kamman K G Go G P Stomp C E Hulstaert H J Berendsen |
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| Institution: | 1. Department of Physical Chemistry, University of Groningen, Nijenborgh 16, 9747 AG Groningen, The Netherlands;2. Department of Neurosurgery, University of Groninge, Nijenborgh 16, 9747 AG Groningen, The Netherlands;3. Centre for Medical Electron Microscopy, University of Groningen, Nijenborgh 16, 9747 AG Groningen, The Netherlands |
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| Abstract: | NMR spectroscopical measurements of relaxation times were conducted on muscle, intestine, fatty tissue and cerebral cortex and white matter of the rat at various time intervals following removal of the tissue. It appeared that most tissues can be stored at 4 degrees C up to 24 hours without noticeable effects on NMR relaxation parameters. Exceptions are the T2 of muscle and the T1 and T2 of intestine, which tended to change in the first hour after biopsy. Relaxation parameters change considerably after fixation of the tissues. Therefore the effects of fixation have to be taken into account when carrying out NMR measurements on fixed tissues. |
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| Keywords: | NMR Proton spin relaxation Rat tissue Biopsy Sample handling Fixation |
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