Radiation sterilization of chitosan sealant for vascular prostheses |
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| Authors: | J Rosiak P Ulański M Kucharska J Dutkiewicz L Judkiewicz |
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| Institution: | (1) Institute of Applied Radiation Chemistry, Technical University of  ód , Wróblewskiego 15, 93-590 ód, (Poland);(2) Institute of Man Made Fibers, Technical University of ód, Zwirki 36, 90-924 ód, (Poland);(3) Laboratory of Hemostasis, Institute of Pathology, Medical Academy of ód, Narutowicza 96, 91-141 ód, (Poland) |
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| Abstract: | Chitosan was used as a sealant of knitted polyester vascular grafts. Three sterilization methods for chitosan-coated prostheses were tested: sterilization with ethylene oxide, formaldehyde and irradiation with gamma rays. Radiation sterilization was found to be the most promising of tested methods. The radiation-induced changes in chitosan irradiated in solid state were investigated. Main chain scission was found as the predominant effect of irradiation. Changes in IR and UV spectra were analyzed. Existence of some post-effects was detected. It seems that the observed increase in biocompatibility of chitosan surface caused by irradiation with sterilizing dose (25 kGy) is due to some structural factor connected with a decrease in molecular weight. |
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