On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles |
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| Authors: | Chimichi Stefano Boccalini Marco Selleri Silvia Costagli Camilla Guerrini Gabriella Viola Giampietro |
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| Affiliation: | Dipartimento di Chimica Organica U. Schiff and Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi (HeteroBioLab), University of Florence, I 50019 Sesto F.no (Firenze), Italy. stefano.chimichi@unifi.it |
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| Abstract: | Reaction of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidine 1 with 1,3- and 1,4-bisnucleophiles has been investigated; obtainment of new polycyclic heterocyclic derivatives is reported. A convenient procedure leading to new pyrazolo[1,5-a]quinazolines is described; a modest bioactivity of these compounds against two human tumor cell lines was also ascertained. |
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